SPI 112 ( SPI-112; SPI112; SPI 112 )

产品货号. M17127 CAS No. 1051387-90-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SPI 112
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.
产品描述

SPI-112, the SPI-112 methyl ester analog was able to inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.
同义词

SPI-112; SPI112; SPI 112
通路

Others
靶点

Other Targets
受体

SHP-2
研究领域

——
适应症

——

CAS Number

1051387-90-6
分子量

468.45
分子式

C22H17FN4O5S
纯度

98%
溶解度

——
SMILES

O=C(O)c1cccc(N/N=C/2\C(=O)Nc3c2cc(S(=O)(=O)NCc2ccc(F)cc2)cc3)c1
化学全称

(Z)-3-(2-(5-(N-(4-Fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid

1.Chen L, et al. Biochem Pharmacol. Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112 . 2010 Sep 15;80(6):801-10

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